Products & Applications

Our premium nicotine has always been the #1 choice for quality e-liquids producers but is now even better. Advanced production technologies now ensure our new NicSelect™ pure nicotine is even higher purity and absolutely crystal clear.

#1 choice for quality e-liquids producers

Light in taste and clear in colour for a superior vaping experience

Near zero impurities significantly exceeding
EP/USP monographs

100% Natural nicotine from carefully selected tobacco leaves

Our Product Range

 

Product

Quality

Application

Regulatory

Documentation

NicSelect™
Nicotine EP / USP
Premium grade pure nicotine cGMP Pharma USDMF, EDMF Technical data sheet MSDS,
GMP certificate
cGMP E-liquids USDMF, EDMF,
REACH, TPD
Technical data sheet
MSDS, GMP certificate
Nicselect™
Nicotine bases
Standard bases:
72mg/ml, 100 mg/ml
Custom bases: 6,12,18mg/ml
Propylene glycol(PG) or Vegetable Glycerin(VG) bases
Premium grade nicotine bases ‘ready to flavour’ cGMP E-liquids REACH, TPD Technical data sheet
MSDS, GMP certificate
Nicotine Ditartrate Dihydrate EP A pure crystalline salt of nicotine in powder format cGMP Pharma USDMF, EDMF Technical data sheet
MSDS, GMP certificate
Tobacco Absolute An original base flavour for a real cigarette taste cGMP E-liquids Technical data sheet
MSDS, GMP certificate
Nicotine Resinate / Nicotine Polacrilex USP/EP A nicotine ion-exchange resin complex for controlled nicotine release to the body cGMP Pharma USDMF, EDMF Technical data sheet
MSDS, GMP certificate
NEW Nicotine Salts Premium grade nicotine
salt bases ‘ready to flavour
cGMP E-liquids TPD Technical data sheet MSDS, GMP/ISO certificate

Introducing


Advanced and enhanced vaping

Made in the EU

Off the shelf or custom base solutions

Made with NicSelect Premium Vaping Grade Nicotine


The original base flavour for a real cigarette taste

Tobacco Absolute (nicotiana tabacum l. leaf absolute) is the natural flavour extracted and refined from tobacco leaves with a sweet, mossy, woody and hay like flavour that is typical of tobacco.

Used in small amounts it is the ideal base aroma for tobacco flavoured e-liquids like American Gold, American Red and the classic French and British blends.


The benefits of nicotine salts

The primary function of organic salt acids in nicotine salts are to help the nicotine salt vaporize at lower temperatures, to lower the pH levels in the nicotine salt, to improve nicotine absorption and to provide a “smoother throat hit” either because of the lower PH or desensitization of the throat. We offer a range of salts as each salt has slightly different modes of action, pharmacokinetics and characteristics. From an organoleptic perspective different salts also seem to work better with different flavours.

Nicotine levulinate

Research indicates that levulinic acid may act to desensitizes the upper respiratory tract potentially allowing for the vaped nicotine to be inhaled deeper into the lungs. Some studies also suggest that levulinic acid also may enhance the binding of nicotine to neurons that ordinarily would be unresponsive to nicotine2. Nicotine levulinate is slightly acidic (around PH 6.0)

Nicotine benzoate

Nicotine benzoate appears to reduce or make neutral the taste of the nicotine and because of the lowered and more neutral PH (around PH 6.5) results in a smoother and softer throat. In research conducted by Li et al, nicotine benzoate was shown to have the best properties in taste, reduction of throat irritation and maintenance of nicotine stability making it one of the main and preferred salts for e-liquids1.

NDD Salt Solution

Nicotine NDD salt is commercialized extensively in smoking cessation products globally and this supported by years of use and research and is nowadays one of the more popular salts found in e-liquids. Nicotine NDD Salt has a near neutral taste when vaped making it a popular choice for formulation with all types of liquids and flavours combinations. Alchem HQ Nicotine NDD Salt Solution has more a pH around 4.5 providing a light and smooth throat hit.

References.

  1. The Effect of Organic Acids on E-liquid : Nicotine Stability and Relief of Irritative Taste. Jingjing Ll”, ShengyiLIU1, Xiuxiang YAN,. Ruvian Technology LTD
  2. Nicotine Tob Res. 2005 Oct;7(5):761-71. Industry research on the use and effects of levulinic acid: a case study in cigarette additives. Keithly L1, Ferris Wayne G, Cullen DM, Connolly GN.

Applications

Alchem International is a leading global manufacturer of natural nicotine and nicotine complexes for use in Tobacco substitutes, including e-cigarettes, nicotine patches, nicotine gums and nicotine lozenges. Alchem NicSelect™ premium nicotine is used extensively in e-cigarettes and other nicotine replacement products throughout Europe, the Unites States and the rest of the world.


e-cigarettes

Since their introduction in 2006, e-cigarettes have reached an estimated global market value of 3 billion USD in 2014. With their exceptional growth and popularity, e-cigarettes have posed a challenge to other smoking cessation products as well as to the tobacco cigarette industry. 1Their rapid growth is expected to continue as consumers chose to avoid tobacco products. As of 2016, with the application of the European TPD (Tobacco Product Directive), the e-liquid and e-cigarette market will be more regulated to ensure a consistent product quality and provide a reference for European consumers. In the US, the next several months will be a challenge for many of Nicotine retailers you as you prepare to adhere to the FDA regulations and the PMTA (pre-market tobacco approval) requirements.

Alchem International NicSelect™ liquid nicotine is manufactured to the highest possible quality standards under pharmaceutical GMP conditions and subject to rigorous analytical controls to ensure the highest purity and lowest impurity levels. This ensures compliance with even the strictest regulations as well as guarantees outstanding quality and consistency. We are REACH and TPD compliant for Europe and will soon be submitting a TPMF (tobacco products master file) on NicSelect™ to the FDA that you can reference in your PMTA applications for the US.

 


Patches, gums & lozenges

The global market size of nicotine replacement therapy (NRT) products reached just above 3 billion USD in 2014 – an increase of almost 300% in a decade. The most common forms are gums, inhalers, lozenges, nasal sprays, skin patches. Today, the market size is similar to those of e-cigarettes and is still growing strongly as new delivery devices are developed and consumers are looking for alternatives to their current tobacco products.

Alchem International produces pharmaceutical-grade liquid nicotine and nicotine powder complexes specifically for these applications in cGMP certified facilities and supported by Drug Master Files (DMFs) for medicinal registration.

 


We are committed to the long-term success of this industry. Please feel free to Contact Us to discuss how we can help you succeed in this ever-changing regulatory landscape.

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